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Simparica kills adult fleas, and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations from lone star ticks, Gulf Coast ticks, American dog tick, black-legged ticks and brown dog ticks for one month in dogs 6 months of age or older and weighing at least 2.8 lbs.
Possible Side Effects
Side effects that usually are not serious include:
- Vomiting, diarrhea.
- Low energy level.
If any of these signs are severe, worsen, or continue to be a problem, contact your veterinarian.
Side effects that may be serious or indicate a serious problem:
- Vomiting or diarrhea that does not stop.
- Tremors, seizures.
- Difficulty walking (eg, weakness, stumbling).
If you see any of these signs, contact your veterinarian immediately.
Drug & Food Interactions
There are no known contraindications to the use of Simparica.
Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. The most frequently reported adverse reactions were vomiting and diarrhea. See full Prescribing Information.
5 mg Sarolaner, Hydrolyzed Soy Protein, Starch, Corn, Wheat Germ, Anhydrous Dibasic Calcium Phosphate, Corn Syrup, Gelatin.
Simparica Trio is given orally once a month, at the recommended minimum dose of 0.54 mg/lb sarolaner, 0.011 mg/lb moxidectin, and 2.27 mg/lb pyrantel (as pamoate salt).
Simparica Trio can be offered to the dog with or without food.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, give Simparica Trio immediately and resume monthly dosing.
Simparica Trio should be administered at monthly intervals year?round
or at least within one month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give Simparica Trio immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, Simparica Trio should be given within one month of the last dose of the former medication.
Flea Treatment and Prevention:
Treatment with Simparica Trio may begin at any time of the year. Simparica Trio should be administered year?round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re?infestation, it is important to treat all dogs and cats within a household with a flea control product.
Tick Treatment and Control:
Treatment with Simparica Trio can begin at any time of the year. Simparica Trio should be administered year?round at monthly intervals or started at least one month before ticks become active.
Intestinal Nematode Treatment and Control:
For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.