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Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets)
is a flavored, chewable tablet for administration to dogs 8 weeks of age and older.
Simparica Trio is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.
Simparica Trio kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black?legged tick), and Rhipicephalus sanguineus (brown dog tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.
Simparica Trio is given orally once a month, at the recommended minimum dose of 0.54 mg/lb sarolaner, 0.011 mg/lb moxidectin, and 2.27 mg/lb pyrantel (as pamoate salt).
Simparica Trio can be offered to the dog with or without food.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, give Simparica Trio immediately and resume monthly dosing.
Heartworm Prevention:
Simparica Trio should be administered at monthly intervals year?round
or at least within one month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give Simparica Trio immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, Simparica Trio should be given within one month of the last dose of the former medication.
Flea Treatment and Prevention:
Treatment with Simparica Trio may begin at any time of the year. Simparica Trio should be administered year?round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re?infestation, it is important to treat all dogs and cats within a household with a flea control product.
Tick Treatment and Control:
Treatment with Simparica Trio can begin at any time of the year. Simparica Trio should be administered year?round at monthly intervals or started at least one month before ticks become active.
Intestinal Nematode Treatment and Control:
For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
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